1、用法不同：be similar to後邊既可以加物主代詞又可以加人，即：be similar to sth/sb be similar with後邊只可以加人 ，即be similar with sb.
例句：
（1）Drop in the earth, down to the river, went straight to the natural away, andChiang Kai-shek peaceful purpose 。
滴在土裏，下到河裏，直奔了自然而去的，中正平和，應與琴旨相近吧。
（2）I know, I suppose it must be similar to the River-Boca rivalry.
我知道。我想這和河床與博卡之間的競爭差不多。
2、是否可以加從句：be similar to後邊可以跟從句，而be similar with不可以。
例句：
（1）To legalize it will be similar to that of horse-racing if this proposal is passed.
合法化會相似，賽馬如果這項建議獲得通過。
（2）The core technology of tissue engineering is utilize the suitable seed-cells compound with organic materials to build a cartilage-like tissue in vitro or in vivo,?
軟骨組織工程的核心技術就是利用合適的種子細胞復合生物材料，在體內或體外構建與人關節透明軟骨形態、結構。
3、釋義不完全相同：be similar with 是某人對什麽很熟悉 ，是主動 ；be similar to 是某物為某人所熟知，與...相似 , 是被動。
例句：
（1）Be similar with economic spatial distribution，the characteristic of populationspatial distribution is spatial centrality.
經濟的空間分布具有集中性特點，人口的空間分布及演化亦是如此。
（2）That would be similar to what apple did with music and the iPod.
這聽起來與蘋果處理音樂和iPod的做法如出壹轍。